3D Printing of Sub-100 Micrometer Cross-section Microfluidic Devices for Preterm Birth Biomarker Analysis

Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

11. Apr 2018
10:30-11:00 h  |  ICM - Internationales Congress Center München Room 4b

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Subjects: 

Pharma & Diagnostics

|

Medicine/public health

|

Biotechnology & Life Sciences

|

Analytic

Speaker: 

Prof. Dr. Adam T. Woolley 

(Brigham Young University)

Type:
Lecture
Speech: English

Our research focuses on the development of integrated microfluidic devices for rapid
and automated analysis of biomarkers that are linked to human health problems. After
utilizing planar microfabrication technologies including soft lithography to create these
microchips for many years, [1] we have concluded that alternative fabrication methods
must be developed for integrated microfluidic systems to achieve their full potential.

We have thus been evaluating stereolithographic 3D printing as an alternative
approach for making complex, integrated microfluidic devices. However, conventional
3D printers are limited in their ability to create embedded fluidic structures with crosssectional
sizes smaller than about 200 micrometers. [2] Hence, we devised an optical
approach for optimizing resin formulations to enable 3D printing of truly microfluidic
(sub-100 micrometer) enclosed features. [3]

To further reduce embedded microfluidic structure sizes in 3D prints, we created our
own 3D printer with advanced patterning capabilities to allow construction of enclosed
20 micrometer by 20 micrometer cross section fluidic features. [4] These 3D-printed
microfluidic devices can contain complex fluidic structures like pumps and valves that
facilitate the integration of analysis functions. [5] We are using 3D-printed devices to
carry out microchip electrophoresis separations of protein and peptide biomarkers
related to preterm birth. We have also demonstrated that porous polymer monolith
chromatographic supports can be created within our 3D prints, allowing for solid-phase
extraction to enrich samples or for immunoaffinity extraction to capture targeted
biomarkers from complex specimens. 3D printing offers a major breakthrough in the
scalable creation of complex and integrated microfluidic devices, leading to an ideal
system for developing miniaturized biomolecular diagnostics.

Literature

[1] Nge, P.N.; Rogers, C.I.; Woolley, A.T. Chem. Rev. 2013, 113, 2550. [2]
Beauchamp, M.J.; Nordin, G.P.; Woolley, A.T. Anal. Bioanal. Chem. 2017, 409, 4311.
[3] Gong, H.; Beauchamp, M.; Perry, S.; Woolley, A.T.; Nordin, G.P. RSC Advances
2015, 5, 106621. [4] Gong, H.; Bickham, B.P.; Woolley, A.T.; Nordin, G.P. Lab Chip
2017, 17, 2899. [5] Gong, H.; Woolley, A.T.; Nordin, G.P. Lab Chip 2016, 16, 2450.

Speaker
Prof. Dr. Adam T. Woolley, Brigham Young University Show Profile

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EntranceEast
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Outdoor areas
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ConferenceCenter Nord
ICM
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Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

Flow-based chemiluminescence microarrays with multilayer plastic foils: cheap, simple, universally applicable

11. Apr 2018
11:00-11:30 h  |  ICM - Internationales Congress Center München Room 4b
Speaker: Dr. Michael Seidel (Technical University of Munich)

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Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

Environmental issues: how analytical chemistry does help

11. Apr 2018
15:00-15:30 h  |  ICM - Internationales Congress Center München Room 4b
Speaker: Dr. Philippe Garrigues (Université de Bordeaux,)

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Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

Raman microscopic imaging for biomedical applications

11. Apr 2018
13:30-14:00 h  |  ICM - Internationales Congress Center München Room 4b
Speaker: Dr. Christoph Krafft (Leibniz Institute of Photonic Technology)

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Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

Analysis of composition and biological activity of emissions from engines and wood combustion

11. Apr 2018
16:30-17:00 h  |  ICM - Internationales Congress Center München Room 4b
Speaker: Prof. Dr. Ralf Zimmermann (Institute of Chemistry, University of Rostock)

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Apr
11
2018

Analytica Conference > GDCh / Raum 4b > ABC-Spotlight on Bio- and Environmental Analysis

Playing tricks on blood cells

11. Apr 2018
14:00-14:30 h  |  ICM - Internationales Congress Center München Room 4b
Speaker: Oliver Hayden (Technical University Munich)

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