Detection of proteins and biopharmaceuticals using aptamers

Apr
10
2018

Analytica Conference > GDCh / Room 3 > Aptamer-based Biosensors

10. Apr 2018
16:00-16:30 h  |  ICM - Internationales Congress Center München Room 3

Additional informations in detail view:
o Attachments
o Presscontact
o Alternative Events

Details

Subjects: 

Analytic

|

Biotechnology & Life Sciences

|

Medicine/public health

|

Pharma & Diagnostics

Speaker: 

Dr. Gabriele Gadermaier 

(University of Salzburg)

Type:
Lecture
Speech: English

Recombinant proteins and in particular biopharmaceuticals (biologics) are produced in heterologous expression systems like bacteria, yeast, plants, insect or Chinese hamster ovary cells. It is well established that minor changes in the production process can lead to subtle differences in protein folding or post-translational modifications. Tight controls are especially relevant during production of biologics as such differences can affect safety, efficacy, quality and stability. Detection of minor conformational changes typically require laborious methods to resolve the tertiary structure, e. g. NMR or x-ray crystallography. An alternative tool is the use of aptamers which can be used to screen 3-dimensional consistency of protein surfaces and thus folding. The specific advantage is the generation of large aptamer panels with different specificities that are in contrast to production of monoclonal antibodies not relying on animal experiments. The presentation provides an overview of aptamers used for detection of proteins and biopharmaceuticals and examples for comparison of biologicals and biosimilars or copy products will be given.

Speaker
Dr. Gabriele Gadermaier (Department of Biosciences), University of Salzburg Show Profile

Location
Outdoor areas
EntranceNorth-East
EntranceNorth-West
EntranceNorth
ConferenceCenter Nord
ICM -InternationalesCongressCenterMünchen
B0
C1
C2
C3
C4
C5
C6
B1
B2
B3
B4
B5
B6
EntranceWest
Atrium
A1
A2
A3
A4
A5
A6
EntranceEast
EntranceNorth-West
EntranceNorth
Outdoor areas
EntranceNorth-East
ConferenceCenter Nord
ICM
B0
C1
C2
C3
C4
C5
C6
B1
B2
B3
B4
B5
B6
EntranceWest
Atrium
EntranceEast
A1
A2
A3
A4
A5
A6
Apr
10
2018

Analytica Conference > GDCh / Room 3 > Aptamer-based Biosensors

Generation of aptamers by in vitro selection

10. Apr 2018
15:00-15:30 h  |  ICM - Internationales Congress Center München Room 3
Speaker: Dr. Marcus Menger (Fraunhofer Institute of Cell Therapy and Immunology)

Additional informations in detail view:
o Attachments
o Presscontact
o Alternative Events

Details
Apr
10
2018

Analytica Conference > GDCh / Room 3 > Aptamer-based Biosensors

Aptamers for cell targeting

10. Apr 2018
15:30-16:00 h  |  ICM - Internationales Congress Center München Room 3
Speaker: Dr. Meltem Avci-Adali (University Hospital Tübingen)

Additional informations in detail view:
o Attachments
o Presscontact
o Alternative Events

Details
Apr
10
2018

Analytica Conference > GDCh / Room 3 > Aptamer-based Biosensors

Detection of small molecules using aptamers

10. Apr 2018
16:30-17:00 h  |  ICM - Internationales Congress Center München Room 3
Speaker: H. Modh

Additional informations in detail view:
o Attachments
o Presscontact
o Alternative Events

Details