Already Analyzing or Still Calibrating? - Demonstration of an online NMR analyzer in pilot scale

Apr
10
2018

Analytica Conference > GDCh / Room 3 > Young Analysts in Process Analytics

10. Apr 2018
14:00-14:30 h  |  ICM - Internationales Congress Center München Room 3

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Subjects: 

Analytic

|

Test and measurement and quality control

Speaker: 

Simon Kern 

(Bundesanstalt für Materialforschung und -prüfung (BAM))

Type:
Lecture
Speech: English

The departure from the current automation landscape to next generation automation concepts for the process industry has already begun. Smart functions of sensors simplify their use and enable plug-and-play integration, even though they may appear to be more complex at first sight. Monitoring specific information (i.e., “chemical” such as physico-chemical properties, chemical reactions, etc.) is the key to “chemical” process control. Here we introduce our smart online NMR sensor module provided in an explosion proof housing as example.

Due to NMR spectroscopy as an “absolute analytical comparison method”, independent of the matrix, it runs with extremely short set-up times in combination with “modular” spectral models. Such models can simply be built upon pure component NMR spectra within a few hours (i.e., assignment of the NMR signals to the components) instead of tedious calibrations runs. We present a range of approaches for the automated spectra analysis moving from statistical approach, (i.e., Partial Least Squares Regression) to physically motivated spectral models (i.e., Indirect Hard Modelling and Quantum Mechanical calculations).

Based on concentration measurements of reagents and products by the NMR analyzer a continuous production and direct loop process control were successfully realized for several validation runs in a modular industrial pilot plant and compared to conventional analytical methods (HPLC, near infrared spectroscopy). The NMR analyser was developed for an intensified industrial process funded by the EU’s Horizon 2020 research and innovation programme (“Integrated CONtrol and SENsing”, www.consens-spire.eu).

Literature:

[1] Meyer, K., Kern, S., Zientek, N., Guthausen, G., & Maiwald, M. (2016). Process control with compact NMR. TrAC Trends in Analytical Chemistry, 83, 39-52.

Speaker
Simon Kern, Bundesanstalt für Materialforschung und -prüfung (BAM) Show Profile

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EntranceEast
EntranceNorth-West
EntranceNorth
Outdoor areas
EntranceNorth-East
ConferenceCenter Nord
ICM
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C1
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C5
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EntranceWest
Atrium
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Apr
10
2018

Analytica Conference > GDCh / Room 3 > Young Analysts in Process Analytics

2D-Fluorescence and UV/Vis Spectroscopy for in-line Bioprocess Monitoring of CHO Cell Cultivations

10. Apr 2018
13:00-13:30 h  |  ICM - Internationales Congress Center München Room 3
Speaker: Jens Claßen (Leibniz Universität Hannover)

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Apr
10
2018

Analytica Conference > GDCh / Room 3 > Young Analysts in Process Analytics

Optical Spectroscopy and Multivariate Data Analysis for Digital Pathology - What do PAT and Point-of-Care Testing have in common?

10. Apr 2018
12:30-13:00 h  |  ICM - Internationales Congress Center München Room 3
Speaker: Mona Stefanakis (Hochschule Reutlingen)

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Apr
10
2018

Analytica Conference > GDCh / Room 3 > Young Analysts in Process Analytics

A new approach to in-line monitoring of biomass growth by Photon Density Wave spectroscopy as an alternative to established optical PAT

10. Apr 2018
13:30-14:00 h  |  ICM - Internationales Congress Center München Room 3
Speaker: Thomas Schiewe (University of Potsdam)

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