Deep phenotyping with metabolomics

Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

12. Apr 2018
16:30-17:00 h  |  ICM - Internationales Congress Center München Room 2

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Subjects: 

Biotechnology & Life Sciences

|

Medicine/public health

|

Pharma & Diagnostics

Speaker: 

Prof. Dr. Jerzy Adamski 

(Helmholtz Zentrum München)

Type:
Lecture
Speech: English

Metabolomics analyses can identify and quantify metabolites present in a
given sample, covering hundreds to thousands of metabolites. Preservation of
metabolomic fingerprint in a sample prior to analysis is a major issue and can
highly affect the data interpretation. The metabolome, although very dynamic,
is stable enough to provide specific quantitative traits related to health and
disease. Major factors influencing the human metabolome are age, sex,
genome, body mass index (BMI), body fat distribution as well as lifestyle
associated aspects like nutrition, alcohol intake, smoking behavior, and
physical activity 1. Further confounders include ethnicity (resulting from the
genetic background and lifestyle), circadian rhythms, hormonal status,
diseases, medications, environmental exposure, as well as the gut microbiota.
Metabolomics has enriched genome wide association studies (GWAS) by
functional data. In indications like diabetes type 2, chronic kidney disease and
cardiovascular diseases the lipids among other chemical classes have been
identified as biomarkers of early disease progression 2.
Literature:
[1] Tokarz, J. et al. Endocrinology Meets Metabolomics: Achievements,
Pitfalls, and Challenges. Trends in endocrinology and metabolism: TEM 28,
705-721, doi:10.1016/j.tem.2017.07.001 (2017). [2] Hocher, B. & Adamski, J.
Metabolomics for clinical use and research in chronic kidney disease. Nature
reviews. Nephrology 13, 269-284, doi:10.1038/nrneph.2017.30 (2017).

Speaker
Prof. Dr. Jerzy Adamski (Genome Analysis Center), Helmholtz Zentrum München Show Profile

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ConferenceCenter Nord
ICM
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Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

Mass Appeal: lessons learnt from large-scale mass spectrometry-based metabolomics

12. Apr 2018
15:30-16:00 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Dr. Royston Goodacre (The University of Manchester)

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Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

Understanding Cancer Metabolism using Metabolomics and Metabolic Flux Analysis

12. Apr 2018
15:00-15:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Zeping Hu (Tsinghua University)

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Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

How Trageted Metabolomics Revolutionized Newborn Screening for Inborn Errors of Metabolism

12. Apr 2018
16:00-16:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Dr. David Millington (Duke University School of Medicine)

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Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

The Sweat Metabolome From Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms Beyond Impaired Chloride Transport

12. Apr 2018
13:00-13:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Dr. Philip Britz-McKibbin (McMaster University)

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Apr
12
2018

Analytica Conference > GBM / Room 2 > Metabolomics: from the discovery of differential metabolites to function elucidation

Metabolic activity of the human brain at rest and during exercise: a complementary metabolomics approach

12. Apr 2018
14:00-14:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Rainer Lehmann (University Hospital Tübingen)

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