Omics data as patterns on biological networks

Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

10. Apr 2018
10:30-11:00 h  |  ICM - Internationales Congress Center München Room 2

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Subjects: 

Biotechnology & Life Sciences

|

Medicine/public health

Speaker: 

Prof. Dr. Marc-Thorsten Hütt 

(Jacobs University,)

Type:
Lecture
Speech: English

Network-based analyses of 'omics' data are a cornerstone of systems medicine. The
statistical task is to quantify the clustering of biological signals (e.g., significant
expression changes) in a network (e.g., a metabolic network or a protein-interaction
network).

Network coherences – topological indices evaluating the connectivity of subnetworks
spanned by the 'omics' signal [1,2] – have been highly successful in identifying patient
subgroups in disease cohorts [2-4].

Underlying this comparison of data with network architectures is the idea of considering
the data as self-organized patterns on graphs.
In this talk I will briefly review this field, starting from investigations of network
architectures and then moving to dynamics on networks and, finally, to the concept of
'omics' data as patterns on graphs and its application to data in biology and medicine.

Literature:

[1] Sonnenschein, Geertz, Muskhelishvili, Hütt (2011) Analog regulation of metabolic
demand. BMC Systems Biology 5, 40.
[2] Sonnenschein, Golib Dzib, Lesne, Eilebrecht, Boulkroun, Zennaro, Benecke, Hütt
(2012) A network perspective on metabolic inconsistency. BMC Systems Biology 6, 41.
[3] Knecht, Fretter, Rosenstiel, Krawczak, Hütt (2016). Distinct metabolic network states
manifest in the gene expression profiles of pediatric inflammatory bowel disease
patients and controls. Scientific Reports, 6, 32584.
[4] Häsler, Sheibani-Tezerji, Sinha, Barann, Rehman, Esser, Aden, Knecht, Nikolaus,
Schäuble, Kaleta, Franke, Fretter, Müller, Hütt, Krawczak, Schreiber, Rosenstiel (2016).
Disturbed congruence of mucosal gene regulation, splicing and adherent microbiota in
inflammatory bowel disease. Gut, gutjnl-2016-311651.

Speaker
Prof. Dr. Marc-Thorsten Hütt, Jacobs University, Show Profile

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Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

Multiomics Identifies Mechanism of Dietary Response

10. Apr 2018
11:30-12:00 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Dr. Andrej Shevchenko

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Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

A systems view of germfree mice reveals that gut microbiota promotes hepatic fatty acid desaturation and elongation

10. Apr 2018
13:30-14:00 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Dr. Josef Ecker (Technische Universität München)

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Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

Multiomics data integration for predictions of metabolic phenotypes

10. Apr 2018
10:00-10:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Aleksej Zelezniak

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Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

Discussion

10. Apr 2018
14:00-14:30 h  |  ICM - Internationales Congress Center München Room 2

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Apr
10
2018

Analytica Conference > GBM / Room 2 > Multiomics

Multi-omics analysis reveals circadian regulation of whole-body lipid metabolism

10. Apr 2018
11:00-11:30 h  |  ICM - Internationales Congress Center München Room 2
Speaker: Prof. Christer Ejsing

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